Computational Sequence Analysis of Foot and Mouth disease Virus in Cattle

Abstract

It has been proven that foot and mouth disease virus (FMDV) is a highly contagious, severe and
economically devastating viral disease worldwide, which affects animals with cloven hoof such as
cattle, deer, pigs, sheep and goats. Thus, this study aimed at investigating the molecular genetic
variation of FMD virus of cattle. A total of twenty FMD virus amino acid sequences of cattle were
retrieved from the GenBank. Various serotypes of FMD virus were identified. The obtained phylogeny
based on amino acid sequences of the FMD virus revealed differential clustering among the
sequences. The predicted 3D FMD protein structures of cattle aligned well with the templates. The
present information on FMDV biodiversity and evolution could be exploited in tracing FMDV sources
and transmission events, as well as to ensure vaccine coverage of corresponding field of FMDV
extractions mostly in a developing country such as Nigeria.