Influence of Lindane or Fenitrothion on the Response to Treatment of Trypanosomosis in Rats

Abstract

Studies were conducted on the influence of the insecticides, lindane or fenitrothion on the course of treatment of
experimental trypanosomosis infection in rats by maluating changes in hematological and biochemical parameters
in groups of animals. Groups of rats were pretreated with either lindane orfenitrothion, infected with Trypanosoma
brucei, before treatment with Berenil7or quinapyramine.
It was observed that the group of animals pretreated with fenitrothion before administration of Berenil7 had
signjficantly (P~0.05h)i gher packed cell volume(PCV),h emoglobin concentration (Hb) total white blood cell
count (WBC) and red blood cell count (RBC) when compared to the untreated control and those treated with berenil
alone. The hematological parametersfrom the gmp of rats pretreated withjhzitrothion befine the use quinapyramine,
were not sign$cantly (P>0.05) differentfrom those treated with quinapyramine alone though the group given
quinapyramine alone showed slightly higher serum biochemical parameters, Nd, Cl-, HC0,2; alkaline phosphatase
(ALP),a lanine aminotransferase(ALT)a, sparta te aminotransferase (AST),a nd serum total protein when compared
to the pretreated group. This may suggest the influence offenitrothion on the metabolism of quinapyramine.
Animals pretreated with lindane befine treating with henil had lower PCV, and Hb compared to the untreated
control and may suggest that lindane had induced the metabolism of berenil. This observation is corroborated by the
higher PCV, Hb, and RBC values of thegroup treated with berenil alone. Furthermore, the observation that the
group pretreated with lindane bqbre administering berenil had lower ALT, and AST compared to the untreated
control group shows that the berenil had started action to reduce the parasitaemia and therqbre tissue damage,
before its metabolism.
Thegroup pretreated with lina'ane b e e giving quinapyramine, had sign$cantly(Pc0.05) lower AS?, ALT,
and serum protein levels compared with the untreated controls. This may suggest the non infZuence oflina'ane on
quinapyramine metabolism.